Sialadenoma papilliferum: 증례보고 및 면역조직화학적 고찰
Sialadenoma papilliferum: a case report and immunohistochemical study review
변준호, 김동철, 고경혁, 박봉욱,
소속 상세정보
변준호 ( Byun June-Ho ) - 경상대학교 의과대학 구강악안면외과학교실
김동철 ( Kim Dong-Chul ) - 경상대학교 의과대학 구강악안면외과학교실
고경혁 ( Go Gyung-Hyuck ) - 경상대학교 의과대학 교정학교실
박봉욱 ( Park Bong-Wook ) - 경상대학교 의과대학 구강악안면외과학교실
KMID : 0355620100360060533
Abstract
Sialadenoma papilliferum (SP) is a rare benign neoplasm that normally arises from the minor salivary glands, particularly in the palate. SP is normally encountered in older men with an exophytic papillary surface growth. In the present study, an SP of the hard palate of a 69-year-old woman was examined immunohistochemically. Myoepithelial cell markers, such as S-100, smooth muscle actin and vimentin, were observed in the basal or luminal layer of tumor cells, indicating that myoepithelial cells participate in the pathogenesis of SP. In addition, cytokeratin 7 was also strongly detected in the tumor cells, suggesting that excretory ductal epithelial cells have a role in its histogenesis. A review of the literature of immunohistochemical studies on SP showed that the expression and co-expression of cytokeratins and myoepithelial cell markers have been reported in tumor cells. These results suggested that excretory duct cells and myoepithelial cells participate in the pathogenesis of SP.
키워드
Sialadenoma papilliferum; Hard palate; Immunohistochemistry
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